These adjustments in myeloma cells that prevent maturation may be induced with the suppression of interferon regulatory factor 4 (IRF4) by hypoxic stress [68,74]. Hypoxia lowers E-cadherin expression, building MM cells move from adhesion of BMSC into peripheral … Continue reading These adjustments in myeloma cells that prevent maturation may be induced with the suppression of interferon regulatory factor 4 (IRF4) by hypoxic stress [68,74]